New research suggests that patients who stop using blockbuster slimming jabs like semaglutide or tirzepatide can put back on lost weight far faster than those who stop traditional lifestyle plans.
Research printed in a leading health publication shows that while obese people can lose substantial amounts of their total mass while using the jabs, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"People buying these treatments need to be informed of the risk of quick rebound weight gain when the therapy concludes," stated expert Dr. Susan Jebb.
This pace of recovery suggests a return to starting mass in about a year and a half.
Comparing Approaches
The research, which looked at 37 of trials involving over 9,000 of participants, contrasted the outcomes of the injectable medications with other pills.
Researchers point out that people who shed pounds through lifestyle changes alone usually see a less rapid creep back—around 0.1 kg a month—after stopping.
The Reason for the Fast Rebound
Nutrition scientists propose the mode of action of the injections accounts for the accelerated regain.
The injections mimic a body's own chemical called glucagon-like peptide-1, which moderates feelings of fullness.
"Sustained high doses of GLP-1 levels several times higher than normal could lead to the system to produce less of its endogenous hormone, and could diminish responsiveness to its effects," explained Dr. Adam Collins, a dietetics expert.
"Withdrawal of this hormone supplement leads to hunger is no longer kept in check, making overeating much more probable."
A Lifelong Condition?
Medical guidelines advise the jabs for individuals with obesity-related health risks, alongside recommended lifestyle changes.
Many experts contend that, considering the high risk of weight regain, the treatment might need to be life-long.
This perspective is reinforced by pharmaceutical companies, who say that the findings "emphasize the persistent nature of obesity," similar to managing diseases like hypertension.
Patient Testimonies
People who have come off the jabs report a intense resurgence of appetite.
"It was like a switch flipping and I was suddenly ravenous," recalled an individual.
This difficulty is worsened if users have not established lasting lifestyle or habit changes during treatment.
Widespread Interest
Figures indicate that a significant number of people in the UK have used these injections in the last 12 months, with desire continuing to grow.
- Use is greater among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, researchers emphasize that while GLP-1 drugs are effective tools for weight loss, they are not a magic fix and lasting health benefits relies on combined lifestyle support.
